Sun Guohui

Personal profile

Name:Sun Guohui

Gender:Male

Degrees:Ph.D.

E-mail:sunguohui@bjut.edu.cn

Current Professional Societies

1. Member of Chinese Chemistry Society;

2. Member of Chinese Pharmacological Society;

3. Member of Chinese Society of Biomedical Engineering

Research Areas

1. Anticancer alkylating agents and tumor resistance;

2. Computational and predictive toxicology;

3. QSAR research in drug discovery and environmental toxicology

Honors

2019 MDPI Outstanding Reviewer Representative Award

Publications

[1] Sun, X. D.; Sun, G. H.*; Huang, Y. X.; Hao Y. X.; Tang, X. Y.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. 3-Bromopyruvate regulates the status of glycolysis and BCNU sensitivity in human hepatocellular carcinoma cells. Biochem. Pharmacol. 2020, 113988. DOI: 10.1016/j.bcp.2020.113988 (IF:4.825)

[2] Sun, X. D.; Sun, G. H.*; Huang, Y. X.; Zhang, S. F.; Tang, X. Y.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. Glycolytic inhibition by 3-bromopyruvate increases the cytotoxic effects of chloroethylnitrosoureas to human glioma cells and the DNA interstrand cross-links formation. Toxicology 2020, 435, 152413. (IF: 3.547)

[3] Hao, Y. X.; Sun, G. H.*; Fan, T. J.; Sun, X. D.; Liu, Y. D.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. Prediction on the mutagenicity of nitroaromatic compounds using quantum chemistry descriptors based QSAR and machine learning derived classification methods. Ecotoxicol. Environ. Safe. 2019, 186, 109822. (IF: 4.527)

[4] Fan T. J.; Sun, G. H.*; Sun X. D.; Zhao, L. J.; Zhong, R. G.; Peng Y. Z. Tumor energy metabolism and potential of 3-bromopyruvate as an inhibitor of aerobic glycolysis: implications in tumor treatment. Cancers, 2019, 11, 317. (IF:6.162)

[5] Sun, G. H.*; Fan, T. J.; Sun, X. D.; Hao, Y. X.; Cui, X.; Zhao, L. J.*; Ren, T.; Zhou, Y.; Zhong, R. G.; Peng, Y. Z. In silico prediction of O6-methylguanine-DNA methyltransferase inhibitory potency of base analogs with QSAR and machine learning methods. Molecules, 2018, 23, 2892. (IF:3.06)

[6] Sun, G. H.; Zhao, L. J.*; Zhong, R. G.; Peng, Y. Z. The specific role of O6-methylguanine-DNA methyltransferase inhibitors in cancer chemotherapy. Future Med. Chem., 2018, 10, 1971-1996. (IF:3.617)

[7] Sun, G. H.; Fan, T. J.; Zhao, L. J.*; Zhou, Y.; Zhong, R. G. The potential of combi-molecules with DNA-damaging function as anticancer agents. Future Med. Chem., 2017, 9, 403-435. (IF:3.617)

[8] Sun, G. H.; Zhang, N.; Zhao, L. J.*; Fan, T. J.; Zhang, S. F.; Zhong, R. G. Synthesis and antitumor activity evaluation of a novel combi-nitrosourea prodrug: Designed to release a DNA cross-linking agent and an inhibitor of O6-alkylguanine-DNA alkyltransferase. Bioorg. Med. Chem., 2016, 24, 2097-2107. (IF:2.802)

[9] Sun, G. H.; Zhao, L. J.*; Fan, T. J.; Ren, T.; Zhong, R. G. Measurement of O6-alkylguanine-DNA alkyltransferase activity in tumour cells using stable isotope dilution HPLC-ESI-MS/MS. J. Chromatogr. B, 2016, 1033, 138-146. (IF:2.813)

[10] Sun, G. H.; Fan, T. J.; Zhang, N.; Ren, T.; Zhao, L. J.*; Zhong, R. G. Identification of the structural features of guanine derivatives as MGMT inhibitors using 3D-QSAR modeling combined with molecular docking. Molecules, 2016, 21, 823. (IF:3.06)

[11] Sun, G. H.; Zhao, L. J.*; Zhong, R. G. The induction and repair of DNA interstrand crosslinks and implications in cancer chemotherapy. Anti-Cancer Agents Med. Chem., 2016, 16, 221-246. (IF:2.18)

[12] Sun, G. H.; Zhao, L. J.*; Fan, T. J.; Li, S. S.; Zhong, R. G. Investigations on the effect of O6-benzylguanine on the formation of dG-dC interstrand cross-links induced by chloroethylnitrosoureas in human glioma cells using stable isotope dilution high-performance liquid chromatography electrospray ionization tandem mass spectrometry. Chem. Res. Toxicol., 2014, 27, 1253-1262. (IF:3.274)

Personal Statement

Dr. Sun received his Ph.D. degree from Beijing University of Technology, Beijing, China in July, 2017. Later, he worked as a Postdoctoral Research Associate in BJUT for two years. After that, he joined Beijing University of Technology as Master's Student Supervisor in August, 2019. His major research interests include the mechanism of anticancer alkylating agents, tumor resistance, QSAR research in drug discovery and environmental toxicology. His main scientific contributions: a) proposed that dG-dC crosslinks can be a biomarker for evaluating the antitumor activity of chloroethylnitrosoureas; b) proposed that glycolytic inhibitors are very promising to reverse the clinical chemoresistance of anticancer agents; c) established predictive QSARomics models for environmental nitroaromatic compounds. He has contributed a lot towards the scientific and academic community with numerous research publications in highly prestigious international journals and various conference presentations home and abroad. He got the 2019 MDPI Outstanding Reviewer’s Representative Award and is the Member of Chinese Chemical Society, Chinese Pharmacological Society and Chinese Society of Biomedical Engineering.