Sun Guohui

Personal profile

Name: Sun Guohui

Gender: Male

Degrees: Ph.D.

Title: Associate Professor

E-mail: sunguohui@bjut.edu.cn

Current Professional Societies

1. Member of Editor Board of Frontiers in Bioscience-Landmark (SCI indexed)

2. Senior member of Chinese Pharmaceutical Association

3. Member of Chinese Chemistry Society

4. Member of Chinese Pharmacological Society

5. Member of Chinese Society of Biomedical Engineering

Research Areas

1. Anticancer alkylating agents and tumor resistance

2. Computational and predictive toxicology

3. QSAR research in drug discovery and environmental toxicology

Honors

2019/2020 MDPI Outstanding Reviewer Representative Awards

Publications

[1] Hao, Y. X.; Sun, G. H.*; Fan, T. J.; Tang, X. Y.; Zhang J.; Liu, Y. D.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. In vivo toxicity of nitroaromatic compounds to rats: QSTR modelling and interspecies toxicity relationship with mouse. Journal of Hazardous Materials, 2020, 399, 122981. (IF: 9.038)

[2] Huang, Y. X.; Sun, G. H.*; Sun, X. D.; Li, F. F.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. The potential of lonidamine in combination with chemotherapy and physical therapy in cancer treatment. Cancers,2020, 12, 3332. (IF: 6.126)

[3] Sun, X. D.; Sun, G. H.*; Huang, Y. X.; Hao Y. X.; Tang, X. Y.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. 3-Bromopyruvate regulates the status of glycolysis and BCNU sensitivity in human hepatocellular carcinoma cells. Biochemical Pharmacology, 2020, 177, 113988. (IF: 4.96)

[4] Sun, X. D.; Sun, G. H.*; Huang, Y. X.; Zhang, S. F.; Tang, X. Y.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. Glycolytic inhibition by 3-bromopyruvate increases the cytotoxic effects of chloroethylnitrosoureas to human glioma cells and the DNA interstrand cross-links formation. Toxicology, 2020, 435, 152413. (IF: 4.099)

[5]Hao, Y. X.;Sun, G. H.*; Fan, T. J.; Sun, X. D.; Liu, Y. D.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. Prediction on the mutagenicity of nitroaromatic compounds using quantum chemistry descriptors based QSAR and machine learning derived classification methods. Ecotoxicology and Environmental Safety,2019, 186, 109822. (IF: 4.872)

[6] Fan T. J.; Sun, G. H.*; Sun X. D.; Zhao, L. J.; Zhong, R. G.; Peng Y. Z. Tumor energy metabolism and potential of 3-bromopyruvate as an inhibitor of aerobic glycolysis: implications in tumor treatment.Cancers, 2019, 11, 317. (IF:6.126, Editor’s Choice)

[7] Sun, G. H.*; Fan, T. J.; Sun, X. D.; Hao, Y. X.; Cui, X.; Zhao, L. J.*; Ren, T.; Zhou, Y.; Zhong, R. G.; Peng, Y. Z. In silico prediction of O6-methylguanine-DNA methyltransferase inhibitory potency of base analogs with QSAR and machine learning methods. Molecules, 2018, 23, 2892. (IF: 3.267, Feature Paper)

[8] Sun, G. H.; Zhao, L. J.*; Zhong, R. G.; Peng, Y. Z. The specific role of O6-methylguanine-DNA methyltransferase inhibitors in cancer chemotherapy. Future Medicinal Chemistry, 2018, 10, 1971-1996. (IF: 3.607)

[9] Sun, G. H.; Fan, T. J.; Zhao, L. J.*; Zhou, Y.; Zhong, R. G. The potential of combi-molecules with DNA-damaging function as anticancer agents.Future Medicinal Chemistry, 2017, 9, 403-435. (IF: 3.607)

[10] Sun, G. H.; Zhang, N.; Zhao, L. J.*; Fan, T. J.; Zhang, S. F.; Zhong, R. G. Synthesis and antitumor activity evaluation of a novel combi-nitrosourea prodrug: Designed to release a DNA cross-linking agent and an inhibitor of O6-alkylguanine-DNA alkyltransferase. Bioorganic & Medicinal Chemistry, 2016, 24, 2097-2107. (IF: 3.073)

[11] Sun, G. H.; Zhao, L. J.*; Fan, T. J.; Ren, T.; Zhong, R. G. Measurement of O6-alkylguanine-DNA alkyltransferase activity in tumour cells using stable isotope dilution HPLC-ESI-MS/MS. Journal of Chromatography B, 2016, 1033, 138-146. (IF: 3.004)

[12] Sun, G. H.; Fan, T. J.; Zhang, N.; Ren, T.; Zhao, L. J.*; Zhong, R. G. Identification of the structural features of guanine derivatives as MGMT inhibitors using 3D-QSAR modeling combined with molecular docking. Molecules, 2016, 21, 823. (IF: 3.06)

[13] Sun, G. H.; Zhao, L. J.*; Zhong, R. G. The induction and repair of DNA interstrand crosslinks and implications in cancer chemotherapy. Anti-Cancer Agents in Medicinal Chemistry, 2016, 16, 221-246. (IF: 2.049)

[14] Sun, G. H.; Zhao, L. J.*; Fan, T. J.; Li, S. S.; Zhong, R. G. Investigations on the effect of O6-benzylguanine on the formation of dG-dC interstrand cross-links induced by chloroethylnitrosoureas in human glioma cells using stable isotope dilution high-performance liquid chromatography electrospray ionization tandem mass spectrometry. Chemical Research in Toxicology, 2014, 27, 1253-1262. (IF: 3.184)

Personal Statement

Dr. Sun received his Ph.D. degree from Beijing University of Technology, Beijing, China in July 2017. Later, he worked as a Postdoctoral Research Associate inthe same group for two years. After the postdoctoral life ended, he joined the Beijing University of Technology as a master degree's supervisor in August 2019. His major research interests include the mechanism of anticancer alkylating agents, tumor resistance, QSAR research in drug discovery and environmental toxicology. His main scientific contributions: a) proposed that dG-dC crosslinks can be a biomarker for evaluating the antitumor activity of chloroethylnitrosoureas; b) proposed that glycolytic inhibitors are very promising to reverse the clinical chemoresistance of anticancer agents; c) established predictive QSARomics models for environmental nitroaromatic compounds. He has a good contribution to the scientific and academic community with numerous research publications in highly prestigious international journals and various presentations in both national and international conferences. He won the 2019 and 2020 MDPI outstanding reviewer's representative awards. He is a member of editor board Frontiers in Bioscience-Landmark (SCI indexed), the senior member of the Chinese Pharmaceutical Association, the member of Chinese Chemical Society, Chinese Pharmacological Society and Chinese Society of Biomedical Engineering.