þ Master Supervisor

Research Area

Jun Cao has long been engaged in cardiovascular basic research and RNA biology research, especially in the areas of diabetic cardiomyopathy and myocardial regeneration. She has been interested in the effects of alternative splicing, alternative polyadenylation, and tRNA fragment regulatory mechanisms on disease onset and progression.

Recruitment direction: Biomedical Engineering (085409); Biology (0710).

I hope you are: Diligent, eager to learn, and self-motivated.

Bibliography

Jun Cao obtained her bachelor degree from Beijing University of Technology, then she received highly competitive full-scholarship to pursue her Ph.D. degree in clinical medicine research at Imperial College London in the UK. After her Ph.D., she went to University of Texas Medical Branch at Galveston in the U.S. for a postdoctoral training, where she successfully obtained funding from American Heart Association. Before returning to China, she completed additional postdoctoral training at Harvard Medical School/Boston Children's Hospital.

Selected Publications

(1) Cao J, Wei Z, Nie Y, Chen HZ. Therapeutic potential of alternative splicing in cardiovascular diseases. EBioMedicine. 2024 Feb 12;101:104995. doi: 10.1016/j.ebiom.2024.104995.

(2) Cao J and Kuyumcu-Martinez MN. Alternative polyadenylation regulation in cardiac development and cardiovascular disease. Cardiovascular Research, 2023.119(6): p. 1324-1335.

(3) Cao J#, Wang X#, Advani V, Lu YW, Malizia AP, Singh GB, Huang ZP, Liu J, Wang C, Mably JD, Chen K*, Wang DZ*. mt-Ty 5´tiRNA regulates skeletal muscle cell proliferation and differentiation. Cell proliferation, 2023: p. e13416.

(4) Cao J#, Verma SK#, Jaworski E, Mohan S, Nagasawa CK, Rayavara K, Sooter A, Miller SN, Holcomb RJ, Ji P, Elrod ND, Powell M, Yildirim E, Wagner EJ, Popov V, Garg NJ, Routh AL* and Kuyumcu-Martinez MN*. RBFOX2 is critical for maintaining alternative polyadenylation patterns and mitochondrial function in myoblasts. Cell Reports 37(5): p. 109910 (2021).

(5) Cao J, Routh AL and Kuyumcu-Martinez MN. Nanopore sequencing reveals full-length Tropomyosin 1 isoforms and their regulation by RNA-binding proteins during rat heart development. Journal of Cellular and Molecular Medicine doi.org/10.1111/jcmm.16795. 2021;00:1–11 (2021).

(6) Cao J, Cowan, D. B. Wang, DZ. RNA-Derived Small RNAs and Their Potential Roles in Cardiac Hypertrophy. Front Pharmacol 11: 572941(2020).

(7) Cao J, Zhao LJ, Jin SB & Zhong RG. Relationship between the molecular structure and the anticancer activity of N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosoureas: A theoretical investigation. Int J Quantum Chem 112, 747-758, doi:10.1002/qua.23042 (2012).

(8) Cao J, Jin SB, Liu W, Bing H, Zhao LJ & Zhong RG. DFT Studies on the Quantitative Structure-activity Relationship of N-(2-chloroethyl)- N'-cyclohexyl-N-nitrosoureas as Anticancer Agents (Proceedings of 3rd International Conference on Biomedical Engineering and Informatics) (2010).