Qiao Aike

Name: Qiao Aike

Gender: Male

Degrees: Ph.D.

Title: Professor

E-mail : qak@bjut.edu.cn; aqiao@hotmail.com

þ Doctoral supervisor

þ Master Supervisor


Current Professional Societies

(1) Committee member, Division of Biophysics, Chinese Society of Biomedical Engineering

(2) Committee member, Division of Biomechanics and Biorheology, Chinese Society of Biophysics

(3) Committee member, Council of Biomechanics in Beijing Association of Biomedical Engineering

(4) Associate Director, Council of Artificial Intelligence, Branch Society of Ultrasound in Medicine, Asia Pacific Health Association

(5) Member, World Association for Chinese Biomedical Engineering


Research Areas

Biomechanics of cardiovascular system; Numerical Simulation of Biomechanics; Endovascular intervention; Implantation/Intervention devices; Biomedical devices

(1) Research on intravascular stents, encompassing modeling, simulation, experimentation, and application. Conduct simulation and experimental studies on hemodynamic issues related to stent interventional therapy for cardiovascular diseases such as aortic stenosis, aortic aneurysms, cerebral aneurysms, and aortic dissections. Perform simulation and experimental research on the mechanical problems of innovative design, structural improvement, fatigue analysis, and corrosion degradation of biodegradable zinc alloy stents. Carry out computational and experimental studies on the coupled dynamics of stent degradation and vascular reconstruction. Extended research includes, but is not limited to, the new structural design and mechanical analysis of stents for tracheal, esophageal, and other tubular structures.

(2) Research on congenital heart diseases, including biomechanical issues in clinical surgical planning and the development of medical devices. Conduct simulation and experimental studies on the biomechanical aspects of surgical and interventional treatments for congenital heart diseases such as abnormal valve pathologies, transposition of the great arteries, tetralogy of Fallot, atrial septal defects, ventricular septal defects, and patent ductus arteriosus. Utilize geometric multiscale hemodynamic numerical simulations based on lumped parameter models and in vitro model experiments using heart-vascular simulation systems to provide theoretical support for improving surgical protocols for congenital heart diseases, developing new medical devices, and expanding clinical applications. Perform mechanical performance analysis and experimental research on surgical devices such as artificial valves, intracardiac tunnel patches, hemostatic materials, artificial blood vessels, and artificial tracheas, laying the mechanical foundation for the development of new materials and 3D-printed surgical instruments.


Editorial Board Member

(1) Associate chief editor, Beijing Biomedical Engineering (in Chinese)

(2) Editor, Journal of Medical Biomechanics (in Chinese)

(3) Editor, Journal of Beijing University of Technology (Natural Sciences Edition) (in Chinese)

(4) Editor, Biological Physics (in Chinese)

(5) Editor, Archives of Clinical Hypertension


Education

(1) Ph.D

Aug.,1996-July,2000

Center of biomedical engineering, Beijing University of Technology.

Major: Fluid mechanics

(2) Master degree

Aug.,1989-Mar.,1992

Department of basic science, Beijing University of Technology

Major: Mechanical CAD

(3) Bachelor degree

Aug.,1985-July,1989

Department of Mechanical Engineering, North China Institute of Electric Power

Major: Mechanical manufacturing


Work experience

Mar.,2007-to date   College of Chemistry and Life Science. Beijing University of Technology

Apr.,1992-Feb.,2007  College of Mechanical Engineering & Applied Electronics Technology, Beijing University of Technology

Sept.,2003-Feb.,2005  Japan Advanced Institute of Science and Technology (visiting scholor)

May,2002-Apr.,2004   Shantou University, Postdoctoral researcher (part-time)


Honors

(1) September 1998: Outstanding Young Backbone Teacher at Beijing University of Technology.

(2) December 1999: The Third Prize for Science and Technology Progress from the State Bureau of Machinery (4th team member, awarded project "CAD System for Mining Dump Trucks", No. 9917816).

(3) December 2004: The Second Prize for Beijing Municipal Science and Technology Award (2nd team member, awarded project "Biomechanics Research on Organs and Tissues", No. 2004基-2-006).

(4) 2013: The honor of "The Most Beloved Teacher in My Heart" at Beijing University of Technology.

(5) 2019: The Nomination Award for "Most Beloved Teacher in My Heart" at Beijing University of Technology.


Publications

(1) Wang Q, Luo X(*), Qiu J, Hu S, Ding X, Du T, Zhang Y, Hou Q, Zhou J, Jin Y, Qiao A (*). Numerical simulation of fluid-structure interaction analysis for the performance of leaflet reimplantation with different types of artificial graft, Computer Methods and Programs in Biomedicine, 2025, 261:108598.

(2) Chen S, Du T, Zhang H, Zhang Y, Qiao A(*). Advances in Studies on Tracheal Stent Design Addressing the Related Complications, Materials Today Bio, 2024, 29:101263.

(3) Guo B, Chen S, Zhang Y, Yang Y, Song H, Zhang Y, Du T, Qiao A(*). A quantitative study of the effects of a dual layer coating drug-eluting stent on safety and efficacy. Journal of Biomechanics, 2024, 176: 112304.

(4) Tao C, Han Y, Du T, Zhang Y, Jin L, Zhang H, Chen S, Wang Q, Wu W, Qiao A (*). The calculation method of blood flow pressure based on four-dimensional flow magnetic resonance imaging and deep learning. Physics of Fluids, 2024,36: 091916.

(5) Chen S, Du T(*), Zhang H, Qi J, Zhang Y, Mu Y, Qiao A(*). Methods for improving the properties of zinc for the application of biodegradable vascular stents. Biomater Adv. 2024, 156:213693.

(6) Tao C, Han Y, Du T, Zhang Y, Jin L, Zhang H, Chen S, Wang Q, Wu W, Qiao A(*). The calculation method of blood flow pressure based on four-dimensional flow magnetic resonance imaging and deep learning. Physics of Fluids, 2024,36: 091916.

(7) Qi J, Zhang H, Chen S, Du T, Zhang Y and Qiao A(*). Numerical Simulation of Dynamic Degradation and Fatigue Damage of Degradable Zinc Alloy Stents. J. Funct. Biomater. 2023, 14(11), 547.

(8) Wei H, Qu Z, Geng Z, Hou Q, Du T, Luo X, Qiu J, Qiao A(*). Effect of transcatheter aortic valve replacement on bicuspid coronary hemodynamics: A numerical study. Medicine in Novel Technology and Devices, 2023, 18(4):100239.

(9) Qu Z, Wei H, Du T and Qiao A(*). Computational simulation of stent thrombosis induced by various degrees of stent malapposition. Front. Bioeng. Biotechnol. 2022, 10:1062529.

(10) Zhang H, Du T, Chen S, Liu Y, Yang Y, Hou Q, Qiao A(*). Finite Element Analysis of Non-Uniform Degradation of Biodegradable Vascular Stents. J. Funct. Biomater. 2022, 13, 152.

(11) Zhang Y, Chen S, Zhang H, Ma C, Du T, Qiao A(*). Model construction and numerical simulation of arterial remodeling after stent implantation with variations of cell concentration. Medicine in Novel Technology and Devices, Volume 16, December 2022, 100144.

(12) Hou Q, Tao K, Du T, Wei H, Zhang H, Chen S, Pan Y, Qiao A(*). A computational analysis of potential aortic dilation induced by the hemodynamic effects of bicuspid aortic valve phenotypes. Comput Methods Programs Biomed. 2022;220:106811

(13) Song H, Qiao A(*). A New Approach through the Eye of a Needle and Its Potential Application in Bioscience. Molecular & Cellular Biomechanics, 2022,19(3), 159-164.

(14) Ma X, Gao B, Tao L, Ding J, Li S, Qiao A(*), Chang Y. Hemodynamic study of the effect of the geometric height of leaflets on the performance of the aortic valve under aortic valve reconstruction. J Thorac Dis 2022;14(5):1515-1525.

(15) Du T, Niu Y, Liu Y, Yang H, Qiao A(*), Niu X(*). Physical and Chemical Characterization of Biomineralized Collagen with Different Microstructures. J. Funct. Biomater. 2022, 13, 57(1-11).

(16) Chen S, Zhang H, Hou Q, Zhang Y and Qiao A (*). Multiscale Modeling of Vascular Remodeling Induced by Wall Shear Stress. Front. Physiol. 2022, 12(1):808999.

(17) Wang S, Wu D, Li G, Peng K, Mu Y, Ohta M, Anzai H, Qiao A(*). Finite element analysis of the mechanical performance of a zinc alloy stent with the tenon-and-mortise structure. Technology and Health Care. 2022;30(2):351-359.

(18) Hou Q, Liu G, Liu N, Zhang H, Qu Z, Zhang H, Li H, Pan Y and Qiao A(*). Effect of Valve Height on the Opening and Closing Performance of the Aortic Valve Under Aortic Root Dilatation. Front. Physiol. 2021,12:697502.

(19) Zhang H, Xia J, Yang Y, Yang Q, Song H, Xie J, Ma Y, Hou Y, Qiao A (*). Branch flow distribution approach and its application in the calculation of fractional flow reserve in stenotic coronary artery. Mathematical Biosciences and Engineering. 2021, 18(5): 5978-5994.

(20) Zhang H, Li G, Hou Q, Yang Y, Wei H, Yang Y, Qu Z, Xie J, Qiao A(*). Research on the Method of Predicting Fractional Flow Reserve Based on Multiple Independent Risk Factors. Front. Physiol. 2021, 12:716877.

(21) Cheng Y, Qiao A, Yang Y and Fan X. Numerical simulation of hemodynamics in two models for total anomalous pulmonary venous connection surgery. Front. Physiol., 2020;11:206.

(22) Fu Y, Qiao A, Yang Y and Fan X. Numerical simulation of the effect of pulmonary vascular resistance on the hemodynamics of reoperation after failure of one and a half ventricle repair. Front. Physiol., 2020;11:207.

(23) Yang Y, Wang J, Qiao A, Fan X. Numerical simulation of the influence of geometric configurations on pressure difference in the intraventricular tunnel. Front. Physiol., 2020,11:133.

(24) Peng K, Qiao A (*), Wang J, Ohta M, Cui X, Mu. Y. A novel structure design of biodegradable zinc alloy stent and its effects on reshaping stenotic vessel. Journal of Mechanics in Medicine and Biology. 2020, 20(6): 2050022.

(25) Cui X, Peng K, Liu S, Ren Q, Li G, Gu Z, Qiao A (*). A Computational Modelling of the Mechanical Performance of a Bioabsorbable Stent Undergoing Cyclic Loading. Procedia Structural Integrity. 2019; 15: 67-74

(26) Cui X, Ren Q, Li G, Li Z, Qiao A (*). Influence of the Realistic Artery Geometry Parameters on a Coronary Stent Fatigue Life.International Journal of Computational Methods, 2019; 16(3):1842006~1-12.

(27) Fu W, Qiao A(*). Pressure Increase after Stent Intervention Treatment for an Aneurysm Accompanied by a Stenosis. International Journal of Computational Methods, 2019;16(3):1842010~1-12.

(28) Song X, Li G, Qiao A(*), Jin Z, Chen Z, You L. Association of Simultaneously Measured Limbs Blood Pressure Differences with Ankle-Brachial Index. International Journal of Computational Methods, 2019,16(3): 1842016-1~10.

(29) Peng K, Cui X, Qiao A(*), Mu Y. Mechanical analysis of a novel biodegradable zinc alloy stent based on a degradation model. Biomed Eng Online. 2019;18(1):39(1-14). Peng K, Qiao A (*), Ohta M, Putra N, Cui X, Mu Y, Anzai H. Structural design and numerical analysis of a novel biodegradable zinc alloy stent. CMES - Computer Modeling in Engineering and Sciences, 2018; 117(1):17-28

(30) Cui X, Ren Q, Li Z, Peng K, Li G, Gu Z, Qiao A(*). Effect of Plaque Composition on Biomechanical Performance of a Carotid Stent: Computational Study. Computer Modeling in Engineering & Sciences, 2018;116(3):455-469

(31) Fu W, Xia Q, Yan R, Qiao A(*). Numerical Investigations of the Mechanical Properties of Braided Vascular Stents. Bio-Medical Materials and Engineering. 2018;29 (1): 81–94.

(32) Qiao A (*), Song X, Peng K, Du G, Li G, Chen Z. Validity of CAVI measurements for diagnosing hypertension in middle-aged and elderly patients and correlations of these measurements with relevant factors. Technology and Health Care. 2017; 25 (S): S125–S134.

(33) Fu W, Cheng G, Yan R, Qiao A(*). Numerical Investigations of the Flexibility of Intravascular Braided Stent. Journal of Mechanics in Medicine & Biology, 2017; 17(4): 1750075.

(34) Han Y, Yang Q, Yang Z, Xia J, Su T, Jin L(*), Qiao A(*), Yu J. Computational fluid dynamics simulation of hemodynamic alterations in sigmoid sinus diverticulum and ipsilateral upstream sinus stenosis after stent implantation in patients with pulsatile tinnitus. World Neurosurg. 2017 Jul 8. pii: S1878-8750(17)31076-8.

(35) Li H, Wei Y, Wang X, Liu T, Gu J, Li Z, Wang M, Zhao Dg, Qiao A, Liu Y, Zhu B. Multi-objective Optimizations of Biodegradable Polymer Stent Structure and Stent Micro-injection Molding Process. Polymers. 2017, 9, 20.

(36) Ma Y, Liu H, Hou Y, Qiao A, Hou Y, Yang Q, Guo Q. Instantaneous Wave-Free Ratio Derived from Coronary Computed Tomography Angiography in Evaluation of Ischemia-Causing Coronary Stenosis: Feasibility and Initial Clinical Research. Medicine. 2017;96(4):e5979.

(37) Li H,Liu T,Wang M,Zhao D,Qiao A,Wang X,Gu J,Li Z,Zhu B. Design optimization of stent and its dilatation balloon using kriging surrogate model. BioMedical Engineering Online, 2017; 16(1).

(38) Song X, Li G, Qiao A (*), Chen Z. Association of Simultaneously Measured Four-limb Blood Pressures with Cardiovascular Function: a Cross-sectional Study. BioMedical Engineering OnLine. 2016, 15(Suppl 2):147

(39) Gu Z, Pan Y, Qiao A (*), Hu X, Dong N, Li X, Liu Y, Shang De. Numerical simulation of closure performance for neo-aortic valve for arterial switch operation. BioMedical Engineering OnLine. 2016 , 15(Suppl 2):150

(40) Li H,Gu J,Wang M,Zhao D,Li Z,Qiao A,  Zhu B. Multi-objective optimization of coronary stent using Kriging surrogate model. BioMedical Engineering OnLine 2016 15(Suppl 2):148

(41) Qiao A(*), Dai X, Niu J and Jiao J. Hemodynamics in stented vertebral artery ostial stenosis based on computational fluid dynamics simulations. Computer Methods in Biomechanics and Biomedical Engineering. 2016; 19(11): 1190-1200.

(42) Ren X, Qiao A(*), Song H, Song G, Jiao L. Influence of Bifurcation Angle on In-stent Restenosis at the Vertebral Artery Origin: A Simulation Study of Hemodynamics. J. Med. Biol. Eng. 2016; 36(4):555–562

(43) Ren X, Fu Y, Qiao A(*). Influence of bifurcation diameter and angle on the vertebral artery origin stenosis: a simulation study of hemodynamics. Journal of Mechanics in Medicine and Biology. 2016; 16(6): 1650079 (1-18).

(44) Berg P, Roloff C, …… Qiao A, et al. The Computational Fluid Dynamics Rupture Challenge 2013–Phase II: Variability of Hemodynamic Simulations in Two Intracranial Aneurysms. Journal of Biomechanical Engineering. 2015;137(12), 121008 (1-13).

(45) Qiao A(*), Pan Y, Dong N. Fluid-Structure Interaction Simulation of Aortic Valve Closure with Various Sinotubular Junction and Sinus Diameters. Annuals of Biomedical Engineering. 2015; 43(6): 1363-1369.

(46) Morsi Y, Hellevik L, Qiao A, Vayalappil MC, Tu J and Yang W. Cardiovascular haemodynamics: Advancement of numerical and experimental diagnostic tools. Advances in Mechanical Engineering.1-3, 2015.

(47) Lu J, Duan W, Qiao A(*). Finite element analysis of mechanics of neovessels with intraplaque hemorrhage in carotid atherosclerosis. BioMedical Engineering OnLine, 2015, 14(Suppl 1):S3 (1-11).

(48) Fu Y, Qiao A(*), Jin L(*), The influence of hemodynamics on the ulceration plaques of carotid artery stenosis J. Mech. Med. Biol. 2015;15(1): 1550008

(49) Qiao A (*), Yin W, Chu B. Numerical simulation of fluid–structure interaction in bypassed DeBakey III aortic dissection. Computer Methods in Biomechanics and Biomedical Engineering. 2015; 18(11):1173-1180

(50) Cito S, Geers AJ, Arroyo MP, Palero VR, Pallarés J, Vernet A, Blasco J, Román L. San , Fu W , Qiao A, Janiga G, Miura Y, Ohta M, Mendina M, and Usera G. Accuracy and Reproducibility of Patient-Specific Hemodynamics Models of Stented Intracranial Aneurysms: Report on the Virtual Intracranial Stenting Challenge 2011. Annals of Biomedical Engineering. 2015; 43(1): 154-167

(51) Qiao A(*), Pan Y, Dong N. Modeling study of aortic root for Ross procedure: a structural finite element analysis. Journal of Heart Valve Disease. 2014;23(6):683-687

(52) Qiao A(*), Han H, Ohta M, and Qian Y. Computational Simulations in the Cardiovascular System. The Scientific World Journal. 2014, 421061

(53) Zhao X, Liu Y, Ding J, Zhang M, Fu W, Bai F, Ren X, Qiao A(*). Multiscale Study on Hemodynamics in Patient-Specific Thoracic Aortic Coarctation. Statistical Atlases and Computational Models of the Heart. Imaging and Modelling Challenges. Lecture Notes in Computer Science, 2014; 8330: pp 57-64

(54) Li Y, Anzai H, Nakayama T, Shimizu Y, Miura Y, Qiao A(*), Ohta M. Simulation of hemodynamics in artery with aneurysm and stenosis with different geometric configuration. Journal of Biomechanical Science and Engineering. 2014;9(1).

(55) Qiao A(*), Zhang Z. Numerical simulation of vertebral artery stenosis treated with different stents. J Biomech Eng. 2014; 136(4):041007-041007-9.

(56) Qiao A(*), Zeng K.Numerical simulation of hemodynamics in intracranial saccular aneurysm treated with a novel stent. Neurological Research, 2013; 35(7): 701-708.

(57) Fu W, Qiao A (*). Study on Hemodynamics in Patient-Specific Thoracic Aortic Coarctation Model. Statistical Atlases and Computational Models of the Heart. Imaging and Modelling Challenges. Lecture Notes in Computer Science, 2013;7746:  pp 1-8

(58) Niu J, Qiao A(*), Jiao L. Hemodynamic analysis of stent expansion ratio for the vertebral artery ostium stenosis intervention. Journal of Mechanics in Medicine and Biology. 2013;13(4):1350058~1-11.

(59) Steinman DA. (*), …, Qiao A, et al. Variability of CFD Solutions for Pressure and Flow in a Giant Aneurysm: The SBC2012 CFD Challenge. Journal of Biomechanical Engineering, 2013; 135(2): 021015,1-13.

(60) Qiao A(*), Nan Q, Liu Y, Chang Y. Can interventional ablation be applied to the treatment of arterial aneurysm? Med Hypotheses, 2013;80 (4):373-375.

(61) Gao F, Qiao A, Matsuzawa T. Numerical Simulation in Aortic Arch Aneurysm. In “Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm Rupture”, ed. Reinhart Grundmann. ISBN 978-953-307-523-5, Publisher: InTech. Publication date: July 2011. pp207-222

(62) Zhang YS, Yang XJ, Wang SZ, Qiao AK, Chen JL, Zhang KY, Liu ZC, Zhao YJ, Zhang Y, Luo B, Li CH. Hemodynamic effects of stenting on wide-necked intracranial aneurysms. Chinese Medical Journal. 2010;123(15): 1999-2003

(63) Fu W, Gu Z, Meng X, Chu B, Qiao A (*). Numerical Simulation of Hemodynamics in Stented Internal Carotid Aneurysm Based on Patient-Specific Model. Journal of Biomechanics. 2010;43(7):1337-1342

(64) Sui Y, Ma B, Chu B, Qiao A (*). Optimization of Anastomotic Configuration in CABG Surgery. Commun Numer Meth Engng. 2009; 25(11):1097-1106.

(65) Qiao A (*), Liu Y. Numerical study of hemodynamics comparison between small and large femoral bypass grafts. Commun Numer Meth Engng. 2008; 24(11):1067-1078.

(66) Qiao A (*), Liu Y. Medical Application Oriented Blood Flow Simulation. Clinical Biomechanics. 2008; 23: S130–S136

(67) Qiao A (*), Li X, Zhang H. Mechanism of the initiation, propagation and treatment of aortic dissection. Journal of Beijing University of Technology. 2007; 33(9):959-963

(68) Qiao A (*), Matsuzawa T. Hemodynamic simulation in a novel design for femoral bypass grafts. Biorheology. 2007;44(2):103-124

(69) Qiao A (*), Liu Y, Guo Z. Wall shear stresses in small and large 2-way bypass grafts. Medical Engineering & Physics, 2006; 28(3): 251-258

(70) Qiao A (*), Liu Y. Influence of graft-host diameter ratio on the hemodynamics of CABG. Bio-medical Materials and Engineering. 2006; 16(3): 189-201

(71) Liu Y, Qiao A, Nan Q, Yang X. Thermal characteristics of microwave ablation in the vicinity of an arterial bifurcation. Int J Hyperthermia. 2006; 22(6): 491-506

(72) Shen L, Qiao A, Ding H, Mo G, Xu G, Du Y, Li M, Chen Z, Zeng Y. An apparatus for studying the response of cultured endothelial cells to stresses. Australas Phys Eng Sci Med. 2006;29(2): 196-202

(73) Ding H, Qiao A, Shen L, Li M, Chen Z, Yu X and Zeng Y. Design of compliance chamber and after-load in apparatus for cultured endothelial cells subjected to stresses. Cell Biol Int. 2006; 30 (5): 439-44

(74) Qiao Y, Li F, Qiao A, Zhang J, Liang K, Zeng Y. Palm print image recovery and de-noising via multi-channel wavelet filter bank. J Med Eng Technol. 2006;30(5):310-314.

(75) Liu Y, Qiao A, Feuchter D, Gabriel W, Zeng Y. Finite element method on numerical simulation of stratum corneum's penetration property. Appl Math Mech-Engl. 2006; 27(4): 469-475

(76) Qiao A (*), Liu Y, Li S, Zhao H. Numerical simulation of physiological blood flow in 2-way coronary artery bypass grafts. Journal of Biological Physics, 2005; 31(2): 161-182

(77) Qiao A (*), Guo X, Wu S, Zeng Y, Xu X. Numerical study of nonlinear pulsatile flow in S-shaped curved arteries. Medical Engineering & Physics. 2004; 26: 545-552

(78) Qiao A (*), Zeng Y, Xu X. Numerical simulations of stenosed femoral artery with symmetric 2-way bypass graft. Bio-Medical Materials and Engineering. 2004; 14(2), 167-174

(79) Qiao A (*), Liu Y, Wu S, Xu X, Zeng Y. Nonlinear motion mechanics model of curved blood vessel. Acta Mechanica Solida Sinica. 2003;16(1):67-73

(80) Qiao A (*), Liu Y, Zeng Y. Numerical simulation of hemodynamics in symmetric 2-way coronary artery bypass graft. Chinese Journal of Computational Mechanics. 2004;21(6):722-727


Personal Statement

He has been a member of the faculty at Beijing University of Technology since 1992. Currently, he is primarily engaged in teaching and research in biomedical engineering, biomechanics, and implantable/interventional medical devices. He has led and participated in approximately 20 research projects, including the National Key R&D Program, National Natural Science Foundation projects, and Beijing Natural Science Foundation projects. He has published over 300 papers, obtained more than 20 patents, and holds over 20 software copyrights.