Current Professional Societies

1. Member of Chinese Chemistry Society

2. Member of Chinese Pharmacological Society

3. Member of Chinese Society of Biomedical Engineering

4. Member of American Chemistry Society

5. Senior member of Chinese Pharmaceutical Association

Research Areas

1. Anticancer alkylating agents and tumor resistance

2. Computational and predictive toxicology

3. QSAR research in drug discovery and environmental toxicology

Honors

2019/2020 MDPI Outstanding Reviewer Representative Awards

Editorial Board Member: Frontiers in Bioscience-Landmark (SCI, IF: 3.115)

Young Editorial Board Member: Chemical Reagents (Chinese Core Journal)

Publications

[1] Chen, S.; Sun, G. H.*; Fan, T. J.; Li, F. F.; Xu, Y. C.; Zhang, N.; Zhao, L. J.; Zhong, R. Ecotoxicological QSAR study of fused/non-fused polycyclic aromatic hydrocarbons (FNFPAHs): Assessment and priority ranking of the acute toxicity to Pimephales promelas by QSAR and consensus modeling methods. Science of the Total Environment, 2023, 876, 162736. (IF: 10.754,JCR Q1)

[2] Tu, J.; Wu, T.; Yu, Q.; Li, J. X.; Zheng, S.; Qi, K. Z.; Sun, G. H.*; Xiao, R.*; Wang, C. W.* Introduction of multilayered magnetic core–dual shell SERS tags into lateral flow immunoassay: A highly stable and sensitive method for the simultaneous detection of multiple veterinary drugs in complex samples. Journal of Hazardous Materials, 2023, 448, 130912. (IF: 14.224, JCR Q1)

[3] Bai, P. Y.; Fan, T. J.; Sun, G. H.*; Wang, X.; Zhao, L. J.; Zhong, R. G. The dual role of DNA repair protein MGMT in cancer prevention and treatment. DNA Repair, 2023, 123, 103449. (IF: 4.354, JCR Q2)

[4] Li, F. F.; Sun, G. H.*; Fan, T. J.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. Ecotoxicological QSAR modelling of the acute toxicity of fused and non-fused polycyclic aromatic hydrocarbons (FNFPAHs) against two aquatic organisms: Consensus modelling and comparison with ECOSAR. Aquatic Toxicology 2023, 255, 106393. (IF: 5.202, JCR Q1)

[5] Hao, Y. X.; Fan, T. J.; Sun, G. H.*; Li, F. F.; Zhang, N.; Zhao, L. J.; Zhong, R. G. Environmental toxicity risk evaluation of nitroaromatic compounds: Machine learning driven binary/multiple classification and design of safe alternatives. Food and Chemistry Toxicology, 2022,170, 113461.(IF: 5.527, JCR Q1)

[6] Li, F. F.; Fan, T. J.; Sun, G. H.*; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. Systematic QSAR and iQCCR modelling of fused/non-fused aromatic hydrocarbons (FNFAHs) carcinogenicity to rodents: reduce unnecessary chemical synthesis and animal testing. Green Chemistry, 2022,2022, 24, 5304. (IF: 11.034, JCR Q1)

[7] Sun, X. D.; Fan, T. J.; Sun, G. H.*; Zhou, Y.; Huang, Y. X.; Zhang, N.; Zhao, L. J.; Zhong, R.G.; Peng, Y.Z. 2-Deoxy-D-glucose increases the sensitivity of glioblastoma cells to BCNU through the regulation of glycolysis, ROS and ERS pathways: In vitro and in vivo validation. Biochemical Pharmacology, 2022,199, 115029. (IF: 6.1, JCR Q1)

[8] Sun, G. H.*; Zhang, Y. F.; Pei, L. Y.; Lou, Y. Q.; M, Y.; Yun, J. Y.; Li, F. F.; Wang, Y. C.; Hao, Z. Q.; Xi, S.; Li, C.; Chen, C. H.; Zhao, L. J.*; Zhang, N.; Zhong, R. G.; Peng, Y. Z. Chemometric QSAR modeling of acute oral toxicity of Polycyclic Aromatic Hydrocarbons (PAHs) to rat using simple 2D descriptors and interspecies toxicity modeling with mouse. Ecotoxicology and Environmental Safety, 2021, 222, 112525. (IF: 7.129, JCR Q1)

[9] Huang, T.; Sun, G. H.*; Zhao, L. J.; Zhang, N.; Zhong, R. G.; Peng, Y. Z. Quantitative Structure-Activity Relationship (QSAR) studies on the toxic effects of nitroaromatic compounds (NACs): A systematic review. International Journal of Molecular Sciences, 2021, 22, 8557. (IF:6.208, JCR Q1)

[10] Zhang, C.; Hong, L.; Ma, N.*; Sun, G. H.* Logic analysis of how the emergency management legal system used to deal with public emerging infectious diseases under balancing of competing interests—the case of COVID-19. Healthcare, 2021, 9, 857. (IF:3.16, JCR Q2)

[11] Ma, N.; Ma, S.; Li, S. J.; Ma, S.*; Pan, X. Z.; Sun, G. H.* The study of spatial safety and social psychological health features of deaf children and children with an intellectual disability in the public school environment based on the visual access and exposure (VAE) model. International Journal of Environmental Research and Public Health, 2021, 18(8), 4322. (IF: 4.614, JCR Q1)

[12] Hao, Y. X.; Sun, G. H.*; Fan, T. J.; Tang, X. Y.; Zhang J.; Liu, Y. D.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. In vivo toxicity of nitroaromatic compounds to rats: QSTR modelling and interspecies toxicity relationship with mouse. Journal of Hazardous Materials, 2020, 399, 122981. (IF: 14.224, JCR Q1)

[13] Huang, Y. X.; Sun, G. H.*; Sun, X. D.; Li, F. F.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. The potential of lonidamine in combination with chemotherapy and physical therapy in cancer treatment. Cancers, 2020, 12, 3332. (IF: 6.575, JCR Q1)

[14] Sun, X. D.; Sun, G. H.*; Huang, Y. X.; Hao Y. X.; Tang, X. Y.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. 3-Bromopyruvate regulates the status of glycolysis and BCNU sensitivity in human hepatocellular carcinoma cells. Biochemical Pharmacology, 2020, 177, 113988. (IF: 6.1, JCR Q1)

[15] Sun, X. D.; Sun, G. H.*; Huang, Y. X.; Zhang, S. F.; Tang, X. Y.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. Glycolytic inhibition by 3-bromopyruvate increases the cytotoxic effects of chloroethylnitrosoureas to human glioma cells and the DNA interstrand cross-links formation. Toxicology, 2020, 435, 152413. (IF: 4.571, JCR Q1)

[16] Hao, Y. X.; Sun, G. H.*; Fan, T. J.; Sun, X. D.; Liu, Y. D.; Zhang, N.; Zhao, L. J.; Zhong, R. G.; Peng, Y. Z. Prediction on the mutagenicity of nitroaromatic compounds using quantum chemistry descriptors based QSAR and machine learning derived classification methods. Ecotoxicology and Environmental Safety, 2019, 186,109822. (IF: 7.129, JCR Q1)

[17] Fan T. J.; Sun, G. H.*; Sun X. D.; Zhao, L. J.; Zhong, R. G.; Peng Y. Z. Tumor energy metabolism and potential of 3-bromopyruvate as an inhibitor of aerobic glycolysis: implications in tumor treatment. Cancers, 2019, 11, 317. (IF: 6.575, JCR Q1, Editor's Choice)

[18] Sun, G. H.*; Fan, T. J.; Sun, X. D.; Hao, Y. X.; Cui, X.; Zhao, L. J.*; Ren, T.; Zhou, Y.; Zhong, R. G.; Peng, Y. Z. In silico prediction of O6-methylguanine-DNA methyltransferase inhibitory potency of base analogs with QSAR and machine learning methods. Molecules, 2018, 23, 2892. (IF: 4.927, JCR Q2) (Feature Paper)

[19] Sun, G. H.; Zhao, L. J.*; Zhong, R. G.; Peng, Y. Z. The specific role of O6-methylguanine-DNA methyltransferase inhibitors in cancer chemotherapy. Future Medicinal Chemistry, 2018, 10, 1971-1996. (IF: 4.767, JCR Q2)

[20] Sun, G. H.; Fan, T. J.; Zhao, L. J.*; Zhou, Y.; Zhong, R. G. The potential of combi-molecules with DNA-damaging function as anticancer agents. Future Medicinal Chemistry, 2017, 9, 403-435. (IF: 4.767, JCR Q1)

[21] Sun, G. H.; Zhang, N.; Zhao, L. J.*; Fan, T. J.; Zhang, S. F.; Zhong, R. G. Synthesis and antitumor activity evaluation of a novel combi-nitrosourea prodrug: Designed to release a DNA cross-linking agent and an inhibitor of O6-alkylguanine-DNA alkyltransferase. Bioorganic & Medicinal Chemistry, 2016, 24, 2097-2107. (IF: 3.461, JCR Q2)

[22] Sun, G. H.; Zhao, L. J.*; Fan, T. J.; Ren, T.; Zhong, R. G. Measurement of O6-alkylguanine-DNA alkyltransferase activity in tumour cells using stable isotope dilution HPLC-ESI-MS/MS. Journal of Chromatography B, 2016, 1033, 138-146.(IF: 3.318, JCR Q2) 

[23] Sun, G. H.; Fan, T. J.; Zhang, N.; Ren, T.; Zhao, L. J.*; Zhong, R. G. Identification of the structural features of guanine derivatives as MGMT inhibitors using 3D-QSAR modeling combined with molecular docking. Molecules, 2016, 21, 823. (IF: 4.927, JCR Q2)

[24] Sun, G. H.; Zhao, L. J.*; Zhong, R. G. The induction and repair of DNA interstrand crosslinks and implications in cancer chemotherapy. Anti-Cancer Agents in Medicinal Chemistry, 2016, 16, 221-246. (IF: 2.527)

[25] Sun, G. H.; Zhao, L. J.*; Fan, T. J.; Li, S. S.; Zhong, R. G. Investigations on the effect of O6-benzylguanine on the formation of dG-dC interstrand cross-links induced by chloroethylnitrosoureas in human glioma cells using stable isotope dilution high-performance liquid chromatography electrospray ionization tandem mass spectrometry. Chemical Research in Toxicology, 2014, 27, 1253-1262. (IF: 3.973, JCR Q2)

[26] Fan, T. J.†; Sun, G. H.†; Zhao, L. J.*; Cui, X.; Zhong, R. G. QSAR and classification study on prediction of acute oral toxicity of N-nitroso compounds. International Journal of Molecular Sciences, 2018, 19, 3015. (Co-first author, IF: 6.208, JCR Q1)

Personal Statement

Dr. Sun received his Ph.D. degree from Beijing University of Technology, Beijing, China at July, 2017. Later, he worked as a Postdoctoral Research Associate in the same group for two years. After the Postdoctoral experience, he formally joined Beijing University of Technology as Master's Supervisor at August, 2019. Since September, 2022, he is Doctoral Supervisor for international students. His major research interests include the mechanism of anticancer alkylating agents, tumor resistance, QSAR research in drug discovery and environmental toxicology. His main scientific contributions: a) proposed that dG-dC crosslinks can be a biomarker for evaluating the antitumor activity of chloroethylnitrosoureas; b) proposed that glycolytic inhibitors are very promising to reverse the clinical chemoresistance of anticancer agents; c) established predictive QSA Romics models for environmental nitroaromatic compounds. He has a good contribution towards the scientific and academic community with numerous research publications in highly prestigious international journals and various presentations in both national and international conferences. He got the 2019 MDPI outstanding reviewer's representative award. He is the member of Chinese Chemical Society, Chinese Pharmacological Society and Chinese Society of Biomedical Engineering.