þ Doctoral supervisor

þ Master Supervisor

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Current Professional Societies

Early Career Advisory Board : Chemical & Biomedical Imaging（ACS）

Research Areas

1. Fluorescence probe

2. Bio-sensing and Bio-imaging

3. Drug delivery and Therapeutics

Publications

Selected papers in main research area:

1. Chen, X.; Liu, J.; Zhang, Y.; Gao, X.*; Su, D.*, Site-Specific Sequence-activatable Fluorogenic Nanomicelles for Precise Detection of Breast Cancer Lung Metastasis, JACS Au, 2024, 4, 2606-2616

2. Bian, Y.^†; Zhang, Y.^†; Hu, B.; Huang, Y.; Liang, W.; Yuan, Q.; Zhang, J.; Gao, X.; Su, D.*, Organ-Targeted Ionizable Lipid Nanoparticles Facilitate Sequence-Activated Fluorogenic Probe for Precise Imaging of Inflammatory Liver Disease, Small, 2024, 20, 2401282.

3. Wang, Y. ^†; Zhang, Y.^†; Li, M.; Gao, X.*; Su, D.*, An efficient strategy for constructing fluorescent nanoprobes for prolonged and accurate tumor imaging,Anal. Chem., 2024, 96, 2481-2490.

4. Meng, C. ^†; Liu, Y. ^†; Ming, Y.; Lu, C.; Li, Y.; Zhang, L.; Su, D.*; Gao, X.; Yuan, Q.*, Enhancing Liver Delivery of Gold Nanoclusters via Human Serum Albumin Encapsulation for Autoimmune Hepatitis Alleviation, Pharmaceutics, 2024, 16, 110.

5. Zhang, Y.; Li, W.; Chen, X.; Xiong, S.; Bian, Y.; Yuan, L.*; Gao, X.*; Su, D.*, Liver-Targeted Near-Infrared Fluorescence/Photoacoustic Dual-Modal Probe for Real-Time Imaging of In Situ Hepatic Inflammation, Anal. Chem., 2023, 95, 2579-2587

6. Chen, X.; Niu, W.; Yuan, Q.*; Zhang, Y.; Gao, X.; Su, D.*, Mapping the endogenous Zn²⁺ in situ during zebrafish embryogenesis by a fluorogenic sensor, Sens. Actuators B Chem., 2023, 376, 132937.

7. Chen, X.; Niu, W.; Du, Z.; Zhang, Y.; Su, D.*; Gao, X.*, ⁶⁴Cu radiolabeled nanomaterials for positron emission tomography (PET) imaging, Chin. Chem. Lett., 2022, 33, 3349-3360.

8. Zhang, Y.^†; Chen, X.^†; Yuan, Q.; Bian, Y.; Li, M.; Wang, Y.; Su, D.*; Gao, X.*, A high-performance enzyme-activated near-infrared probe for the sensing and tracking of tumor-related NQO1 in cells and in vivo, Sens. Actuators B Chem., 2022, 354, 131129.

9. Zhang, Y.; Chen, X.; Yuan, Q.; Bian, Y.; Li, M.; Wang, Y.; Gao, X.*; Su, D.*, Enzyme-activated near-infrared fluorogenic probe with high-efficiency intrahepatic targeting ability for visualization of drug-induced liver injury, Chem. Sci., 2021, 12, 14855-14862.

10. Chen, X.; Zhang, Y.; Yuan, Q.; Li, M.; Bian, Y.; Su, D.*, Gao, X.*, Bioorthogonal chemistry in metal clusters: a general strategy for the construction of multifunctional probes for bioimaging in living cells and in vivo, J. Mater. Chem. B, 2021, 9, 6614-6622.

11. Su, D.*; Chen, X.; Zhang, Y.; Gao, X.*, Activatable imaging probes for cancer-linked NAD (P) H: quinone oxidoreductase-1 (NQO1): advances and future prospects, TrAC-Trend Anal Chem, 2020, 133, 116112.

12. Su, D.; Gao, L.; Gao, F.; Zhang, X.; Gao, X.*, Peptide and Protein Modified Metal Clusters for Cancer Diagnostics, Chem. Sci., 2020, 11, 5614.

13. Chen, T.; Jiang, L.; Yuan, H. Q.; Zhang, Y.*; Su, D.*; Bao, G. M.*, A Flexible Paper-Based Chemosensor for Colorimetric and Ratiometric Fluorescence Detection of Toxic Oxalyl Chloride, Sens. Actuators B Chem., 2020, 319, 128289.

14. Cai, P. ^†; Su, D. ^†; Yang, W.; He, Z.; Zhang, C.; Liu, H.; Liu, Z.; Zhang, X.; Gao, L.; Liu, Yu.; Jiang, H.; Gao, F.*; Gao, X.*, Inherently PET/CT Dual Modality Imaging Lipid Nanocapsules for Early Detection of Orthotopic Lung Tumors，ACS Appl. Bio Mater., 2020, 3, 611-621.

Before joining BJUT

15. Duan, C.^†; Zhang, J. F. ^†; Hu, Y., Zeng, L.*; Su, D.*; Bao, G. M.*, A distinctive near-infrared fluorescence turn-on probe for rapid, sensitive and chromogenic detection of sulfite in food, Dyes Pigments, 2019, 162, 459-465.

16. Su, D. ^†; Teoh, C. L. ^†; Park, S. J.; Kim, J. Y.; Samanta, A.; Bi, R.; Dinish, U. S.; Olivo, M.; Piantino, M.; Louis, F.; Matsusaki, M.; Kim, S. S.; Bae, M. A.; Chang, Y. T.*, Seeing Elastin: A Near-Infrared Zwitterionic Fluorescent Probe for In Vivo Elastin Imaging, Chem, 2018, 4, 1128-1138.

17. Wu, J.; Pan, J.; Ye, Z.; Zeng, L.*; Su, D.*, A smart fluorescent probe for discriminative detection of hydrazine and bisulfite from different emission channels, Sens. Actuators B Chem., 2018, 274, 274-284.

18. Ye, Z.; Xiong, C.; Pan, J.; Su, D.*; Zeng, L.*, Highly photostable, lysosome-targeted BODIPYs with green to near-infrared emission for lysosome imaging in living cells, Dyes Pigments, 2018, 155, 30-35.

19. Alamudi, S. H. ^†; Su, D. ^†; Lee, K. J.; Lee, J. Y.; Belmonte-Vázquez, J. L.; Park, H. S.; Peña-Cabrera, E.; Chang, Y. T.*, A Palette of Background-Free Tame Fluorescent Probes for Intracellular Multi-Color Labelling in Live Cells, Chem. Sci., 2018, 9, 2376-2383. (Co-first authors).

20. Wang, L. ^†; Su, D. ^†; Berry, S. N.; Lee, J. Y.; Chang, Y. T.*, A New Approach for Turn-on Fluorescence Sensing of L-DOPA, Chem. Commun., 2017, 53, 12465-12468. (Co-first authors). (IF: 6.3)

21. Su, D.; Teoh, C. L.; Wang, L.; Liu, X.; Chang, Y. T.*, Motion-induced change in emission (MICE) for developing fluorescent probes, Chem. Soc. Rev., 2017, 46, 4833-4844. (Back inside cover article)

22. Su, D. ^†; Teoh, C. L. ^†; Gao, N.; Xu, Q. H.; Chang, Y. T.*, A Simple BODIPY-Based Viscosity Probe for Imaging of Cellular Viscosity in Live Cells. Sensors, 2016, 16, 1397. (Co-first authors)

23. Teoh, C. L.^†; Su, D.^†; Sahu, S.; Yun, S. W.; Drummond, E.; Prelli, F.; Lim, S.; Cho, S.; Ham, S.*; Wisniewski, T.*; Chang, Y. T.*, Chemical Fluorescent Probe for Detection of Aβ Oligomers, J. Am. Chem. Soc., 2015, 137, 13503-13509. (Co-first authors), this work was chosen as cover article and selected as JACS Spotlights, J. Am. Chem. Soc., 2015, 137, 10017-10017.

24. Su, D.; Teoh, C. L.; Samanta, A.; Kang, N. Y.; Park, S. J.; Chang, Y. T.*, The Development of a Highly Photostable and Chemically Stable Zwitterionic Near-Infrared Dye for Imaging Applications, Chem. Commun., 2015, 51, 3989-3992.

25. Su, D.; Teoh, C. L.; Kang, N. Y.; Yu, X.; Sahu, S.; Chang, Y. T.*, Synthesis and Systematic Evaluation of Dark Resonance Energy Transfer (DRET)-based Library and Its Application in Cell Imaging, Chem. Asian J., 2015, 10, 581-585.

26. Su, D.; Oh, J.; Lee, S. C.; Lim, J. M.; Sahu, S.; Yu, X.; Kim, D.; and Chang, Y. T.*, Dark to light! A new strategy for large Stokes shift dyes: coupling of a dark donor with tunable high quantum yield acceptors, Chem. Sci., 2014, 5, 4812-4818.

27. Su, D.; Teoh, C. L.; Sahu, S.; Das, R. K.; Chang, Y. T.*, Live cells imaging using a turn-on FRET-based BODIPY probe for biothiols, Biomaterials, 2014, 35, 6078-6085.

Personal Statement

Dongdong Su received his MS degree in organic chemistry from Nankai University in 2010 and his PhD degree in 2014 from the National University of Singapore under the supervision of Prof. Young-Tae Chang. After postdoctoral research in Prof. Chang’s group at the Singapore Bioimaging Consortium, A*Star (2014–2018), he worked at Beijing University of Technology as a professor. His research focuses on the development of smart molecular probes/nanoprobes for bioimaging.

We are thrilled to welcome you to join our research group! It is with great excitement that we embark on this journey together, exploring the fascinating world of "fluorescence probe". We are confident that your time with us will be both rewarding and inspiring.

Welcome to the team! We are excited to see the contributions you will make and look forward to achieving great things together.