Current Professional Societies

1. Member of Chinese Chemical Society;

2. Reviewer of Letters in Organic Chemistry, Journal of Organic Chemistry Tetrahedron Letters, Organic & Biomolecular Chemistry, Chemical Biology & Drug Design, Ultrasonics Sonochemistry, Journal of Polymer Science, Bioorganic & Medicinal Chemistry Letters, and etc.

Research Areas

1. General Fields of Organic Synthesis Chemistry;

2. Speciality in the synthesis of polyhedron, Anti-HIV Drug, Anti-tumor Drug and New Compounds

Honors

1. Two Third Prizes Of Beijing Municipal Science And Technology Progress Award;

2. Nova Of Beijing Science And Technology;

3. Beijing Youth Outstanding Teachers

Publications

1. Wenzhi Ma, Yanyu Wang, Dongchen Chu, Hong Yan*, 4D-QSAR And MIA-QSAR Study On The Bruton's Tyrosine kinase (Btk) Inhibitors, Journal Of Molecular Graphics And Modelling 92 (2019) 357-362

2. Shengquan Hu, Zhichang Zhao, Hong Yan*. Discovery And Optimization Of 5,7-Dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one Derivatives As mTORC1/mTORC2 Dual Inhibitors. Bioorganic Chemistry, 201, 103232

3. Shengquan Hu, Wuji Sun, Yeming Wang, Hong Yan*, Design, Synthesis, And Anticancer Activities Of Halogenated Phenstatin Analogues As Microtubule Destabilizing Agent, Medicinal Chemistry Research, Medicinal Chemistry Research, 2019, 28(4), 465-472

4. Keli Cui, Meng Gao, Hongyi Zhao, Dongfeng Zhang*, Hong Yan,*And Haihong Huang* An Efficient Synthesis Of Aryl Substituted Pyrroles By The Suzuki-Miyaura Coupling Reaction Of SEM-protected pyrroles, Molecules 2019, 24, 1594

6. Fan Q, Duan X, Yan H*. Solid State [2+2] Photocycloaddition For Constructing Dimers Of N,N’-diacyl-1,4-dihydropyrazines Based On Thiourea-induced Assembly[J]. Cryst Eng Comm, 2018, 20:1151-1157.

7. Qiangwen Fan, Peng Li, Hong Yan*, Photophysical Properties Of 2,6-Unsubstituented 1,4-Dihydropyridines: Experimental And Theoretical Studies, Journal Of Photochemistry And Photobiology A: Chemistry, 2018, 358, 51-60.

8. Tan H, Zhao Z, Yan H*. Highly Regioselective Photodimerization Of 1,4-Dihydropyridines: An Efficient Synthesis Of Novel 3,6-Diazatetraasteranes[J]. Tetrahedron, 2018, 74(6):529-534.

9. Wuji Sun, Shengquan Hu, Shubiao Fang, Hong Yan*, Design, Synthesis And Biological Evaluation Of Pyrimidine-based Derivatives As VEGFR-2 Tyrosine Kinase Inhibitors, Bioorganic Chemistry, Volume 78, 2018, 393–405

10. Wuji Sun, Qiangwen Fan, Hong Yan*, Manipulating [2+2] Photodimerization Of 1,4-Dihydropyridines Within γ-Cyclodextrin, Journal Of Photochemistry And Photobiology A: Chemistry, Journal Of Photochemistry And Photobiology A: Chemistry 359 (2018) 33–39

11. Wuji Sun, Shubiao Fang, Hong Yan*, Discovery Of Novel Picolinamide-based Derivatives As Novel VEGFR-2 kinase Inhibitors: Synthesis, In Vitro Biological Evaluation And Molecular Docking, Med Chem Comm, 2018, 9, 1054 - 1058

12. Qiangwen Fan, Hongbo Tan, Peng Li, Hong Yan,* Hetero-intermolecular [2+2] Photoaddition Of 1,4-Dihydropyridines: A Combined Experimental And DFT Study, New Journal Of Chemistry, 2018,42, 16795 – 16805

13. Qiangwen Fan, Hongbo Tan, Yeming Wang & Xiuqing Song, Hong Yan*, Conformational Analysis Of Ticagrelor: Effect Of Noncovalent Interaction On Conformational Population, Structural Chemistry (2018) 29:1663–1670

14. Qiangwen Fan, Runzhi Sun, Zhichang Zhao, Hong Yan*, Synthesis And The Oretical Study Of Pyrrole Formiate Derivatives Through Ring Contraction Of 1,4-Dihydropyridines, Tetrahedron, 2018, 74,7457-7465

15. Hong-bo Tan, Xiu-qing Song, Hong Yan*, Hong-xing Xin Synthesis, NMR Analysis And X-ray Crystal Structure Of 3-(2-naphthoyl)-6,12-diphenyl-3,9-diazatetraasterane, Journal Of Molecular Structure, Volume 1129, 5 February 2017, Pages 23-31

16. Qidi Zhong; Qiangwen Fan; Hong Yan*, Synthesis Of 2,3-dihydropyrroles By Photo Rearrangement Of Hantzsch 1,4-Dihydropyridines With High Diastereoselectivity, Tetrahedron Letters, 2017, 58, 1292–1295

17. Hongxing Xin, Xiaohe Zhu, Hong Yan,* And Xiuqing Song，Revelation From The Reaction Of 1,4-Diazabutadiene With Perchloric Acid: An Approach To The Synthesis Of Imidazolium Perchlorates，J. Heterocyclic Chem., 2016, 53, 1363–1366.

18. Yeming Wang, Hong Yan*, Synthesis And Anticancer Activities Of Novel 8-Azapurine Carbocyclic Nucleoside Hydrazones, Bioorganic & Medicinal Chemistry Letters, 2015, 25, 4461–4463.

19. Wuji Sun, Yangye Jiang, Hong Yan*, Synthesis And Photoreaction Of 2-Amino-3-cyano-4-aryl-4H-pyrans, Aust. J. Chem. 2015, 68, 273–281.

20. Xiaowei Duan, Hongxing Xin, Hong Yan*. Design, Synthesis, And Biological Evaluation Of 1,4-Diaryl-1,4-dihydropyrazines As Novel 11β-HSD1 Inhibitors. Biological & Pharmaceutical Bulletin, 2014, 37(5), 840-846.

Personal statement

Yan Hong, professor and doctoral supervisor, is engaged in the photochemical synthesis and biochemical research of organic compounds with biochemistry. She presided over and participated in a number of scientific research projects in the synthesis, antiviral and anti-tumor activities of polyhedral alkanes and their derivatives. She published more than 100 papers in foreign and domestic core journals. At present, she focuses on research and development of antiviral and anti-tumor drugs, as well as innovative drugs, which are based on the methods of drug synthesis and extraction, separation and modification of effective components of natural products.